A new approach to the treatment of recurrent aphthous stomatitis with bioadhesive gels containing cyclosporine A solid lipid nanoparticles: in vivo/in vitro examinations.

摘要: AIM To develop a suitable buccal bioadhesive gel formulation containing cyclosporine A solid lipid nanoparticles (CsA SLNs) for the treatment of recurrent aphthous stomatitis. METHODS The suitability prepared formulations application was assessed by means rheological studies, textural profile analysis, and ex vivo drug-release studies. Plastic flows, typical gel-like spectra, mechanical properties were obtained from formulations. retention time explored in distribution studies effect CsA SLNs on healing oral mucosal ulceration investigated an animal model. In are very important indicator at site. RESULTS Distribution showed that 64.76% ± 8.35% coded "F8+SLN" remained mucosa 6 hours after application. For second part experiments, 36 rabbits separated into three groups: first group treated with without active agent; SLNs; third group, used as control received no treatment. Wound established scoring rate wound Days 3, 6, 9, 12. Histological observations made same days included increased repair significantly. CONCLUSION This study has shown reported here is promising candidate topical