The Chemistry of Glycoproteins at the Surfaces of Tumor Cells

摘要: Glycoproteins probably participate actively in most of the multiple and diverse functions attributed to mammalian cell surface, such as active transport (Kraemer, 1971), contact inhibition (Abercrombie Ambrose, 1962), histotypical recognition (Moscona, 1956), transplantation rejection (Sanderson et al., antigen suppression (Apffel Peters, 1970). Yet, there is little firm evidence implicating any particular glycoprotein surface these activities, and, indeed, very has yet been reported regarding chemical structure or biological role a 1971). Since rich carbohydrate material (Bennett, 1963), since glycoproteins appear region (Molnar, 1967), either part external plasma outer membrane macromolecules rooted extended outward from cell, it would that progress isolation characterization be rapid. Because extreme heterogeneity glycoproteins, however, because lack technical means sufficiently sensitive deal with minute quantities generally available, this not so. Nevertheless, determinations composition periphery certain cells have made, some important information structures reported.