Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver
作者： I Björkhem , T Miettinen , E Reihnér , S Ewerth , B Angelin
DOI: 10.1016/S0022-2275(20)38603-X
关键词:
摘要: The possibility that the serum concentrations of various cholesterol precursors may reflect activity hepatic HMG-CoA reductase was investigated in humans under different conditions. levels squalene, free and esterified lanosterol, (4 alpha, 4 beta, 14 alpha-trimethyl-5 alpha-cholest-8, 24-dien-3 beta-ol), two dimethylsterols beta-dimethyl-5 beta-cholest-8-en-3 beta-ol methostenols alpha-methyl-5 alpha-cholest-7-en-3 alpha-cholest-8-en-3 lathosterols (5 5 beta-ol) desmosterol (cholest-5, were measured untreated patients (n = 7) treated with cholestyramine (QuestranR, 8 g twice daily for 2-3 weeks, n 5) or chenodeoxycholic acid (15 mg/kg body weight 3-4 8) prior to elective cholecystectomy. microsomal liver biopsies taken connection operation.(ABSTRACT TRUNCATED AT 250 WORDS)
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