Rubidium-containing mesoporous bioactive glass scaffolds support angiogenesis, osteogenesis and antibacterial activity
作者： Xiang He , Yong Liu , Yanni Tan , Liam M. Grover , Jian Song
DOI: 10.1016/J.MSEC.2019.110155
关键词:
摘要: Abstract In this study, rubidium-containing mesoporous bioglass (Rb-MBG) scaffolds were formed with the investigation of influence Rb addition on angiogenic and osteogenic differentiation abilities hBMSC. The phase composition, microstructure, pore size distribution, ion release, biological activity, drug loading rate, release rate Rb-MBG characterized. proliferation hBMSC, markers bone formation (ALP, COL-1) angiogenesis (VEGF, HIF-1α), wnt/β-catenin related-signaling pathway gene studied by cell culture. loaded antibacterial agents enoxacin (ENX), coliforms Staphylococcus aureus cultured together to study effects. results indicate that samples have a 350–550 μm large structure 4.5–5.5 nm size. Adding can increase activity ALP, secretion VEGF COL I, expression HIF-1α hBMSCs. containing MBG is likely enhance hBMSCs through Wnt/s-catenin signal path. scaffold load effectively ions ENX continuously damage bacterial membrane synergistic effect, therefore achieve results. conclusion, adding supports osteogenesis hBMSCs, as well activity.
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