In silico Mechano-Chemical Model of Bone Healing for the Regeneration of Critical Defects: The Effect of BMP-2

摘要: The healing of bone defects is a challenge for both tissue engineering and modern orthopaedics. This problem has been addressed through the study scaffold constructs combined with mechanoregulatory theories, disregarding influence chemical factors their respective delivery devices. Of involved in process, morphogenetic protein-2 (BMP-2) identified as one most powerful osteoinductive proteins. aim this work to develop validate mechano-chemical regulatory model effect BMP-2 on large silico. We first collected range quantitative experimental data from literature concerning effects cellular activity, specifically proliferation, migration, differentiation, maturation extracellular matrix production. These were then used define governed by stimuli simulate under following conditions: natural healing, an empty hydrogel implanted defect soaked defect. For latter condition, successful was predicted, agreement previous vivo experiments. Further comparisons showed potential model, which accurately predicted formation during distribution across quantity inside proposed also estimated cells evolution defects. novel silico tool provides valuable insight regeneration strategies.