Urinary orotic acid-to-creatinine ratios in cats with hepatic lipidosis.

摘要: OBJECTIVE To determine urinary orotic acid (OA) concentration and evaluate the OA-to-creatinine ratio (OACR) in cats with hepatic lipidosis (HL). ANIMALS 20 HL clinically normal cats. PROCEDURE Hepatic was diagnosed on basis of clinical signs, results serum biochemical analyses, exclusion other concurrent illness, cytologic or histologic evaluation liver biopsy specimens. Urine samples were collected from each cat frozen at -20 C until assayed. creatinine concentrations determined, using an alkaline picrate method followed by spectrophotometric assay. OA high-performance liquid chromatography. Minimum amount detectable feline urine 1 microg/ml. Because small interfering peaks near base peak, minimum quantifiable determined to be 5 Urinary OACR compared both groups RESULTS Differences not detected between HL. Peaks for any Of cats, 14 did have OA. 6 that had peaks, 3 values <5 CONCLUSIONS Apparently, does increase significantly CLINICAL RELEVANCE is a useful diagnostic test