Graphene and hydroxyapatite self-assemble into homogeneous, free standing nanocomposite hydrogels for bone tissue engineering

作者: Xingyi Xie , Kaiwen Hu , Dongdong Fang , Lihong Shang , Simon D. Tran

DOI: 10.1039/C5NR01107H

关键词:

摘要: Graphene-nanoparticle (NP) composites have shown potential in applications ranging from batteries to, more recently, tissue engineering. Graphene and NPs should be integrated into uniform free-standing structures for best results. However, to date, this has been achieved only few examples; most cases, graphene/NP powders lacking three-dimensional (3D) structure were produced. Here we report a facile universal method that can used synthesize such based on colloidal chemistry. We start aqueous suspensions of both graphene oxide nanosheets citrate-stabilized hydroxyapatite (HA) NPs. Hydrothermal treatment the mixtures reduces graphene, entraps HA 3D network thanks self-assembled graphite-like shell formed around it. Dialysis through causes NP deposition onto walls. The resulting graphene-HA gels are highly porous, strong, electrically conductive biocompatible, making them promising scaffolds bone This applied produce variety graphene-based nanocomposites with unprecedented homogeneity.

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