WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake.

摘要: Adipose (adp) is an obesity gene in Drosophila and mice with crucial functions fat metabolism. We investigated the correlation between genetic variation of WDTC1 locus, ortholog adp, human obesity. Five single-nucleotide polymorphisms (SNPs) were genotyped 935 1,115 adults two ethnically diverse US populations. In Boston Puerto Rican population, we demonstrated that SNPs strongly associated Homozygote heterozygote carriers major allele i22835A, representing ∼96% had significantly higher mean BMI (31.5 31.0 kg/m2, respectively) than noncarriers (28.6 kg/m2). Conversely, homozygotes minor i22835G leaner 74% less likely to be overweight or obese (odds ratio (OR) = 0.26, P 0.003) compared homozygote allele. Haplotype analyses based on further supported these findings. addition, found a strong interaction monounsaturated fatty acid (MUFA) intake by genotype this population. As dietary MUFA increased, SNP i22835A>G BMIs, whereas lower BMIs. A white population also exhibited pattern association genotypes although different nature. Those variants which have experienced positive selection history, when food supply was unpredictable. Given high frequency alleles both populations, suggest may important risk factor contributing