Tumor-associated neoexpression of the pS2 peptide and MUC5AC mucin in primary adenocarcinomas and signet ring cell carcinomas of the urinary bladder.

摘要: To gain more detailed insight into the histogenesis of primary nonurachal adenocarcinomas and signet ring cell carcinomas urinary bladder, we analyzed by immunohistochemistry expression a broad panel proteins, associated with differentiation (pS2 peptide, MUC5AC, MUC6, spasmolytic polypeptide, cyclooxygenases-1 -2, caveolin-1), various novel known or candidate tumor suppressors (14-3-3 sigma, SYK, PTEN, maspin). Included were 12 admixed to urothelial carcinomas, 10 pure 5 carcinomas. As most important finding, majority three quarters (72.7%) expressed pS2 nearly half (45.5%) as well observed secrete MUC5AC apomucin. Since both proteins was absent in normal nonneoplastic urothelium, their tumor-associated appearance is regarded neoexpression reexpression, respectively, normally cryptic antigenic determinants, assumed be involved phenotypical formation vesical adenocarcinomas, including The variants glandular an extracellular mucus production support concept that may histogenetically develop from preexistent TCC. Adenocarcinomas which peptide glycoprotein are proposed subclassified intestinal type, distinguished those common type lacking expression. suppressor genes showed loss protein ranging 54.5% sigma), 31.8 (PTEN), 27.3% (SYK) 18.2% (maspin). Similar profiles coexistent argue against specific involvement these during morphogenesis adenocarcinomas.