Distribution and biomarkers of carbon-14-labeled fullerene C60 ([14C(U)]C60) in female rats and mice for up to 30 days after intravenous exposure

摘要: A comprehensive distribution study was conducted in female rats and mice exposed to a suspension of uniformly carbon-14-labeled C60 ([14C(U)]C60). Rodents were administered [14C(U)]C60 (~0.9 mg kg−1 body weight) or 5% polyvinylpyrrolidone-saline vehicle alone via single tail vein injection. Tissues collected at 1 h 1, 7, 14 30 days after administration. separate group rodents received five daily injections suspensions either with tissue collection post exposure. Radioactivity detected over 20 tissues all time points. The highest concentration radioactivity each point liver, lungs spleen. Elimination < 2% urine feces any 24 [14C(U)]C60-retinol liver together accounted for ~99% ~56% the total recovered postexposure, respectively. blood exposure fourfold higher than mice; still circulation both species (<1%). Levels oxidative stress markers increased by 5 remained elevated, while levels inflammation initially then returned control values. level cardiovascular marker von Willebrand factor, rats, but mice. This demonstrates that is retained little elimination i.v. exposure, leads systemic stress. Copyright © 2015 John Wiley & Sons, Ltd.