Problems associated with erythropoietin receptor determination on tumor cells

摘要: Erythropoietin is a glycoprotein hormone which regulates erythropoiesis by stimulating proliferation, preventing apoptosis and inducing differentiation of red blood cell precursors in the bone marrow (Spivak 2005). Not surprisingly, erythropoietin receptors (EPO-R) were first observed these target erythroid cells (D’Andrea Zon 1990). Various studies confirm that number located on surface low, range 100−<2,000 per More recently, EPO-R has been reported tissues outside hematopoietic system (e.g. liver, uterus, central nervous system, heart, vascular endothelium malignant tumors) (Farrell Lee 2004; Jelkmann Wagner 2004). This led to speculation may have an additional pleiotropic role, eliciting tissue protective response following ischemic stress or injury (Boogaerts 2006).