Association of antepartum vitamin D deficiency with postpartum depression: a clinical perspective

摘要: ObjectivePostpartum depression affects up to 20 % of new mothers within the first 12 months parturition. 25-Hydroxyvitamin D (25(OH)D) has known importance in bone health, but it may also play an important role other functions, including reproduction and fertility, immune function mental health. This clinical commentary reviews literature evaluating 25(OH)D deficiency during pregnancy incidence postpartum depressive symptomatology.DesignNarrative review, summary recommendations.Setting/ParticipantsA search revealed five relevant studies antepartum women, three based USA, one Turkey Iran.ResultsThree measured serum concentrations or second trimester discovered association with symptoms postpartum. One study determined almost significant (P=0·058) inverse relationship first-trimester concentration postpartum, last study, which was a secondary analysis, did not find association.ConclusionsThe Endocrine Society recommends routine vitamin supplementation lactation due increased metabolic demand mother, recent Cochrane review recommended against screening. Vitamin should be target more period since appears have for both medical is relatively safe cost-effective intervention pregnancy, prove prevention depression.