Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
作者： Borcherng Hong , Bruno Tse , Sepehr Sarshar
DOI:
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摘要: The present invention is directed to compounds having the structure (I) wherein R1, R2, R3, R4, R5 and m are as defined herein. of this novel therapeutic agents for treatment cancer, metabolic diseases skin disorders in mammalian subjects. These also useful modulators gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. thus regulating cell differentiation cycle processes that controlled or regulated various hormones cytokines. In particular, relates induce apoptosis cancer cells therefore may be used prevention including advanced cancers pre-cancerous cells. discloses pharmaceutical compositions methods disease mammals.
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