Dietary procyanidins lower triglyceride levels signaling through the nuclear receptor small heterodimer partner
作者： Josep Maria Del Bas , Marie Louise Ricketts , Isabel Baiges , Helena Quesada , Anna Ardevol
关键词:
摘要: Hypertriglyceridemia is an independent risk factor in the development of cardiovascular diseases, and we have previously reported that oral administration a grape seed procyanidin extract (GSPE) drastically decreases plasma levels triglycerides (TG) apolipoprotein B (ApoB) normolipidemic rats, with concomitant induction hepatic expression nuclear receptor small heterodimer partner (NR0B2/SHP). Our objective this study was to elucidate whether SHP mediator reduction TG-rich ApoB-containing lipoproteins triggered by GSPE. We show GSPE inhibited TG ApoB secretion human hepatocarcinoma HepG2 cells had hypotriglyceridemic effect wild-type mouse. The TG-lowering action abolished transfected SHP-specific siRNA SHP-null Moreover, mouse liver, downregulated several lipogenic genes, including steroid response element binding protein 1c (SREBP-1c), upregulated carnitine palmitoyltransferase-1A (CPT-1A) A5 (ApoA5), SHP-dependent manner. In also secretion, but SHP-independent conclusion, key This novel signaling pathway procyanidins through may be relevant explain health effects ascribed regular consumption dietary flavonoids.
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