摘要: The effects of viral immune evasion proteins can occur outside host cells, in the case chemokines, cytokines, or cell surface receptors, inside signal transduction and antigen presentation pathways. This chapter attempts to summarize examples strategies, especially facets system frequently targeted by viruses. Human cytomegalovirus (HCMV), human retroviruses, vaccinia virus incorporate complement control (CCPs), CD55 CD59, into virion envelopes, mediating resistance complement. poxviruses variola virus, (VV), cowpox (CPV) all express CCPs, which were discovered based on sequence similarity mouse CCPs. ability viruses induce IFN gene expression via dsRNA varies greatly, have evolved intercept this dsRNA-dependent activation function either block IFN-induced transcription neutralizing molecules that establish an antiviral state. discovery virus-encoded homologs regulatory factors (vIRFs) within genome herpesvirus 8 (HHV-8) suggested a mechanism whereby homolog could outcompete cellular IRFs needed for transcriptional response genes. Inactivation occurs only after direct contact between herpes simplex (HSV)-infected fibroblasts lymphocytes, not when lymphocytes are incubated with high concentrations cell-free virus.
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