Frontal areas contribute to reduced global coordination of resting-state gamma activities in drug-naïve patients with schizophrenia.

摘要: Schizophrenia has been postulated to involve impaired neuronal cooperation in large-scale neural networks, including cortico-cortical circuitry. Alterations gamma band oscillations have attracted a great deal of interest as they appear represent pathophysiological process cortical dysfunction schizophrenia. Gamma reflect local activities, and the synchronization these activities among spatially distributed areas suggested play central role formation networks. To assess global coordination across brain regions, Omega complexity (OC) multichannel EEG was proposed. Using OC, we investigated resting-state both (30–50 Hz) below-gamma (1.5–30 bands drug-naive patients with schizophrenia effects neuroleptic treatment. We found that OC significantly higher compared control subjects right frontal electrode (F3) contributed OC. After treatment, reductions contribution electrodes correlated improvement symptomatology. The present study suggests processes were less coordinated activity remaining brain. In addition, beneficial treatment accompanied by predominantly due changes regions. Our provides new evidence improper intrinsic integration investigating activity.