Prospects of miRNA-based therapy for pancreatic cancer.
作者： Priya Pai , Satyanarayana Rachagani , Chandrakanth Are , Surinder Batra
DOI: 10.2174/13894501113149990181
关键词:
摘要: Pancreatic cancer (PC) is the fourth leading cause of related deaths in U.S., with a less than 6% five-year survival rate. Treatment confounded by advanced stage disease at presentation, frequent metastasis to distant organs time diagnosis and resistance conventional chemotherapy. In addition, molecular pathogenesis unclear. The extensive study miRNAs over past several years has revealed that are frequently de-regulated pancreatic contribute aggressiveness disease. Several studies have tackled practical difficulties application as viable therapeutic diagnostic tools. Given single miRNA can affect myriad cellular processes, successful targeting agents could likely yield dramatic results. current review attempts summarize advances field assesses prospects for profiling aiding PC treatment.
eurekaselect.com参考文章(97)
Rusty L Montgomery, Eva van Rooij, Therapeutic advances in MicroRNA targeting. Journal of Cardiovascular Pharmacology. ,vol. 57, pp. 1- 7 ,(2011) , 10.1097/FJC.0B013E3181F603D0
Michael T McManus, MicroRNAs and cancer Seminars in Cancer Biology. ,vol. 13, pp. 253- 258 ,(2003) , 10.1016/S1044-579X(03)00038-5
Laisheng Li, Xinhua Xie, Jinmei Luo, Min Liu, Shaoyan Xi, Jiaoli Guo, Yanan Kong, Minqing Wu, Jie Gao, Zeming Xie, Jun Tang, Xi Wang, Weidong Wei, Mingtian Yang, Mien-Chie Hung, Xiaoming Xie, Targeted Expression of miR-34a Using the T-VISA System Suppresses Breast Cancer Cell Growth and Invasion Molecular Therapy. ,vol. 20, pp. 2326- 2334 ,(2012) , 10.1038/MT.2012.201
Richard W Carthew, Gene regulation by microRNAs. Current Opinion in Genetics & Development. ,vol. 16, pp. 203- 208 ,(2006) , 10.1016/J.GDE.2006.02.012
Shuomin Zhu, Min-Liang Si, Hailong Wu, Yin-Yuan Mo, MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1) Journal of Biological Chemistry. ,vol. 282, pp. 14328- 14336 ,(2007) , 10.1074/JBC.M611393200
Kiranmai Gumireddy, Douglas D. Young, Xin Xiong, John B. Hogenesch, Qihong Huang, Alexander Deiters, Small‐Molecule Inhibitors of MicroRNA miR‐21 Function Angewandte Chemie. ,vol. 47, pp. 7482- 7484 ,(2008) , 10.1002/ANIE.200801555
Rui Yi, Yi Qin, Ian G Macara, Bryan R Cullen, Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs Genes & Development. ,vol. 17, pp. 3011- 3016 ,(2003) , 10.1101/GAD.1158803
T Kawaguchi, S Komatsu, D Ichikawa, R Morimura, M Tsujiura, H Konishi, H Takeshita, H Nagata, T Arita, S Hirajima, A Shiozaki, H Ikoma, K Okamoto, T Ochiai, H Taniguchi, E Otsuji, Clinical impact of circulating miR-221 in plasma of patients with pancreatic cancer. British Journal of Cancer. ,vol. 108, pp. 361- 369 ,(2013) , 10.1038/BJC.2012.546
Vivien Wang, Wei Wu, MicroRNA-Based Therapeutics for Cancer BioDrugs. ,vol. 23, pp. 15- 23 ,(2009) , 10.2165/00063030-200923010-00002
Eun Joo Lee, Yuriy Gusev, Jinmai Jiang, Gerard J. Nuovo, Megan R. Lerner, Wendy L. Frankel, Daniel L. Morgan, Russell G. Postier, Daniel J. Brackett, Thomas D. Schmittgen, Expression profiling identifies microRNA signature in pancreatic cancer. International Journal of Cancer. ,vol. 120, pp. 1046- 1054 ,(2006) , 10.1002/IJC.22394