Regioselective C–H and N–H functionalization of purine derivatives and analogues: a synthetic and mechanistic perspective

摘要: Purines, which are heterocyclic compounds built up of fused pyrimidine and imidazole rings, serve as ubiquitous structural cores nucleic acids (DNA RNA), natural products, bio-active molecules, pharmaceuticals. Among a variety synthetic approaches toward purines, selective functionalization through C–H/N–H bond activation has undergone rapid development in the past few years. Since purines have several bonds with distinct reactivities, strategies that allow for regioselective is central issue. This perspective offers an overview recent methods purine functionalization. The reported categorized according to type being formed, e.g. C–CH2–, C–CH, C–C, C–X (I, Br), C–CN, C–N, C–Si, N–C. covers most advances C2–H, C6–H, C8–H, N7–H N9–H well their scope, limitations, mechanisms practical applications.