Novel Therapeutic Strategies for Castration Resistant Prostate Cancer: Inhibition of Persistent Androgen Production and Androgen Receptor Mediated Signaling

摘要: Purpose: Androgen receptor signaling remains essential for many prostate cancers that have progressed despite androgen deprivation therapy. After medical or surgical castration persistent though not insignificant low levels of androgens are produced from nongonadal sources, such as the adrenal glands. Some resistant acquire ability to convert steroids androgens, maintaining sufficient activate receptor. Inhibition production and mediated relevant therapeutic strategies cancer.Materials Methods: The scientific foundation clinical experience with secondary hormonal therapy well development new investigational agents cancer, specifically selective cytochrome p450 17 inhibitors second generation antiandrogens, discussed.Results: Selective inhibition has emerged an importa...