Influence of high titers of maternal antibody on the serologic response of infants to diphtheria vaccination at three, five and twelve months of age.

摘要: Diphtheria antitoxin was determined in serum from 44 pregnant women, of whom 26 had received one injection diphtheria toxoid during pregnancy. Their infants were vaccinated with a combined diphtheria-tetanus vaccine at 3, 5 and 12 months age. This vaccination schedule has been used Sweden since 1986, replacing the old 4.5 6 age originally designed for diphtheria-tetanus-pertussis vaccine, which not after cessation general against pertussis 1979. Serum samples obtained 7 18 After 2 injections mothers high titers, > or = 0.1 IU/ml, tended to have lower titers than low concentrations (P 0.067). All children had, however, above minimum protective level 0.01 IU/ml. Median 1.6 IU/ml both groups third booster injection. Four who pregnancy 0.4 did reach injections: all 4 responded dose. Thus primed by doses irrespective maternal antibody concentration. The repressive effect on noted no longer observed third,