Role of β-Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy

摘要: Activation of the sympathetic nervous system (SNS) releases norepinephrine, stimulates β-adrenoceptors, and plays a crucial role in development cardiac hypertrophy upon activation various cellular signaling pathways heart. At early stages, norepinephrine-induced serves as an adaptive mechanism for maintaining heart function whereas at late it is associated with contractile dysfunction, alterations electrical activity, programmed cell death. G s -protein coupled β 1- or 2-adrenoceptors produces increase contractility some deleterious effects that i 2- 3-adrenoceptors known to result beneficial actions While involves downstream adenylyl cyclase (AC), -proteins either depression AC augmentation guanylate activity. In this article, we discuss physiological aspects β-adrenergic their modification hypertrophied well participation transition failure. Furthermore, highlight components β-adrenoreceptor cascade may participate genesis thus serve pharmacological targets prevention treatment failing