Liposomal Delivery of P-Ethoxy Antisense Oligodeoxynucleotides in Chronic Myelogenous Leukemia

摘要: Liposomes have been used widely as drug delivery vehicles. Recently, we focused our studies on the liposomal of nucleic acids. We and others reported feasibility using liposomes to deliver various acid analogues, such phosphodiesters (Thierry Dritschilo, 1992; Ropert et al, 1993; Thierry Tari 1995), phosphorothioates Bennett Busch 1994; Lappalainen 1994), methyl phosphonates (Tari 1994). In this chapter, will present findings another analogue, P-ethoxy oligodeoxynucleotides (oligos). oligos are uncharged analogues in which an ethyl group has added nonbridging oxygen atom phosphate bonds. P-ethoxys were first synthesized by (1971) found be resistant against nuclease digestion (Miller 1974) could bind DNA with higher binding affinity than their phosphodiester counterparts 1971).