Perinatal Nitric Oxide Therapy Prevents Adverse Effects of Perinatal Hypoxia on the Adult Pulmonary Circulation

摘要: Adverse events in utero are associated with the occurrence of chronic diseases adulthood. We previously demonstrated mice that perinatal hypoxia resulted altered pulmonary circulation adulthood, a decreased endothelium-dependent relaxation arteries, long-term alterations nitric oxide (NO)/cyclic GMP pathway. The present study investigated whether inhaled NO (iNO) administered simultaneously to could have potential beneficial effects on adult circulation. Indeed, iNO is therapy choice humans presenting neonatal hypertension. Long-term not yet been investigated. Pregnant were placed (13% O2) simultaneous administration 5 days before delivery until after birth. Pups then raised normoxia Perinatal completely restored acetylcholine-induced relaxation, as well endothelial synthase protein content, isolated arteries born hypoxia. Right ventricular hypertrophy observed old compared controls was also prevented by treatment. Therefore, during hypoxic exposure seems able prevent adverse