CXCL12 and CCL20 play a significant role in mucosal T-lymphocyte adherence to intestinal microvessels in mice.

摘要: Objective: Although it is known that the chemokines CXCL12 and CCL20 are expressed in intestine, their contribution to lymphocyte homing has not been investigated detail. The authors whether CXCL12-CXCR4 CCL20-CCR6 systems involved T lymphocyte–endothelial interaction microvessels of small large intestines.Methods: Labeled lamina proprial lymphocytes (LPLs) were administered mice, adhesion normal TNF-α –induced inflamed intestinal mucosa was observed under an intravital microscope. Antibodies against CXCL12, CCL-20, or CCL-25 prior administration, some experiments CXCR4 CCR6 on LPLs desensitized with excess amount chemokine.Results: adhered ileum colon, induced a significant accumulation at both sites. Blocking system significantly inhibited LPL colon –tre...