Advances in aquaporin-2 trafficking mechanisms and their implications for treatment of water balance disorders

摘要: In mammals, conservation of body water is critical for survival and dependent on the kidneys ability to minimize loss in urine during periods deprivation. The collecting duct channel aquaporin-2 (AQP2) plays an essential role this homeostatic response by facilitating reabsorption along osmotic gradients. increase levels AQP2 apical plasma membrane following osmolality a rate-limiting step reabsorption, process that tightly regulated antidiuretic hormone arginine vasopressin (AVP). review, focus carboxyl-terminus as key regulatory point trafficking. We provide overview structure, disease-causing mutations carboxyl-terminus, post-translational modifications such phosphorylation ubiquitylation tail domain, their implications balanced trafficking AQP2. Finally, we discuss how various facilitate selective protein:protein interactions modulate mechanism.