Genotyping of AR and PSA polymorphisms in a patient with Klinefelter syndrome, non-Hodgkin lymphoma, and adenocarcinoma of the prostate.
作者： Rodrigo Mattos dos Santos , Claudia Aparecida Rainho , José Carlos Souza Trindade , José Carlos Souza Trindade Filho , João Lauro Viana de Camargo
DOI: 10.1016/J.CANCERGENCYTO.2004.01.002
关键词:
摘要: It has been hypothesized that the AR (androgen receptor) gene binds two PSA (prostate-specific antigen) alleles with differing affinities and may differentially influence prostate cancer risk. In this article, we report a case of adenocarcinoma in 56-year-old man Klinefelter syndrome (47,XXY) non-Hodgkin lymphoma, as well genotype. polymorphisms were analyzed by polymerase chain reaction-based methods using DNA from peripheral white blood cells cancer. We determined methylation status on X chromosome. The patient presents AG genotype for ARE-1 response element) region gene. detect presence short 19 11 CAG repeats each. Unmethylated demonstrated both. shorter allele was inactive more than 60% total both control cells. G contribute to development 47,XXY patient.
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