Interaction between sex hormones and WNT/β-catenin signal transduction in endometrial physiology and disease.

摘要: Wnt/β-catenin signalling plays a rate-limiting role in early development of many different organs broad spectrum organisms. In the developing Mullerian duct, is important for initiation, outgrowth, patterning and differentiation into vagina, cervix, uterus oviducts. adult life, sex hormones modulate endometrium to maintain monthly balance between estrogen-induced proliferation progesterone-induced differentiation, enhanced seems be involved endometrial carcinogenesis. However, pregnancy prerequisite proper implantation invasion trophoblast cells myometrium thus helping form placenta. Overall, it that tight control time space normal function female reproductive tract. if not kept check, easily initiate or contribute number uterine disorders.