No association between G1359A CB1 polymorphisms and pain in young northeastern Mexicans.

作者: Ismael A Rodríguez-Rodríguez , Karla A Fernandez-Quiroga , Pilar DC Morales-San Claudio , Isaías Balderas-Rentería , Omar González-Santiago

DOI: 10.2217/PGS-2018-0125

关键词:

摘要: Aim Recent studies show an association between the endocannabinoid system and pain. In this study, we analyzed two CNR1 gene polymorphisms pain perception in a northeast Mexican population. Methods Genotypic allelic frequencies were obtained for both polymorphisms. Pain threshold, tolerance measured using cold pressor task. Results No significant was found (p > 0.05). Conclusion reported first time population; however, our results suggest that there is not these

参考文章(54)
C M Gérard, C Mollereau, G Vassart, M Parmentier, Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochemical Journal. ,vol. 279, pp. 129- 134 ,(1991) , 10.1042/BJ2790129
Hui-Chen Lu, Ken Mackie, An Introduction to the Endogenous Cannabinoid System. Biological Psychiatry. ,vol. 79, pp. 516- 525 ,(2016) , 10.1016/J.BIOPSYCH.2015.07.028
Roger G Pertwee, Emerging strategies for exploiting cannabinoid receptor agonists as medicines British Journal of Pharmacology. ,vol. 156, pp. 397- 411 ,(2009) , 10.1111/J.1476-5381.2008.00048.X
Enza Palazzo, Livio Luongo, Vito de Novellis, Francesco Rossi, Sabatino Maione, The Role of Cannabinoid Receptors in the Descending Modulation of Pain Pharmaceuticals, policy and law. ,vol. 3, pp. 2661- 2673 ,(2010) , 10.3390/PH3082661
A Milewicz, U Tworowska-Bardzińska, D Jędrzejuk, F Lwow, K Dunajska, Ł Łaczmański, M Pawlak, Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women International Journal of Obesity. ,vol. 35, pp. 373- 377 ,(2011) , 10.1038/IJO.2010.145
Rachel Müller, Alexandra L. Terrill, Mark P. Jensen, Ivan R. Molton, Craig Ravesloot, Catherine Ipsen, Happiness, Pain Intensity, Pain Interference, and Distress in Individuals with Physical Disabilities. American Journal of Physical Medicine & Rehabilitation. ,vol. 94, pp. 1041- 1051 ,(2015) , 10.1097/PHM.0000000000000294
Paola Russo, Pasquale Strazzullo, Francesco P. Cappuccio, David A. Tregouet, Fabio Lauria, Maria Loguercio, Gianvincenzo Barba, Marco Versiero, Alfonso Siani, Genetic Variations at the Endocannabinoid Type 1 Receptor Gene (CNR1) Are Associated with Obesity Phenotypes in Men The Journal of Clinical Endocrinology and Metabolism. ,vol. 92, pp. 2382- 2386 ,(2007) , 10.1210/JC.2006-2523
Nicholas Henschke, Steven J. Kamper, Chris G. Maher, The Epidemiology and Economic Consequences of Pain Mayo Clinic Proceedings. ,vol. 90, pp. 139- 147 ,(2015) , 10.1016/J.MAYOCP.2014.09.010
Janaína P. Jaeger, Vanessa S. Mattevi, Sidia M. Callegari-Jacques, Mara H. Hutz, Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population Disease Markers. ,vol. 25, pp. 67- 74 ,(2008) , 10.1155/2008/841490