Does Smoking Affect the Ki67 and p53 Expressions in Asymptomatic Fully Impacted Lower Third Molar Follicles?

摘要: Purpose Ki67 and p53 protein expressions are the most widely used markers to show pathologic proliferation early-stage tumoral alterations in vital tissues. The aim of this study was compare smokers' nonsmokers' pericoronal follicles asymptomatic impacted lower third molars (ILTMs). Materials Methods A cross-sectional planned. sample derived from a population patients who presented for evaluation operative treatment ILTMs. predictor variable smoking status, defined as smoker or nonsmoker. Outcome variables were ILTM follicles. Other age, gender, tooth position, cigarette pack-year, epithelial layer staining, inflammation. Independent-samples t test analyses conducted with SPSS 10.0 (SPSS, Inc, Chicago, IL), statistical significance set at P value equal .05. Results composed 70 (35 group) contributed 60 There differences between 2 groups p53. Mean expression levels 3.93 ± 2.17 2.48 2.09, respectively, smokers nonsmokers (  = .011). expression levels 5.32 1.98 3.06 2.34, .000). Conclusion present showed that dental have higher than