Immunohistochemical localization of coagulation, fibrinolytic and antifibrinolytic markers in adenocarcinoma of the lung.

摘要: Extravascular coagulation and fibrinolysis are intimately involved in modulate cancer cell growth, invasion metastasis. Samples from resection specimens of patients with primary lung (adenocarcinomas) were tested monoclonal (MAb) polyclonal (PAb) antibodies against various factors the or systems, antigens inflammatory proliferating cells. MAb Ki-67 specific to nuclear cells showed a distinct but variable staining nuclei throughout tumor tissue. Nests tissue stained cytokeratin-specific (PKK1), whereas other parts negative. Fibrin(ogen) fibronectin found stroma alveolar lining, most densely areas at transition zone between normal Fibrinolytic system components like plasminogen activators (t-PA), urokinase (u-PA), their inhibitors PAI-1 PAI-2 all studied. All negative for t-PA (except endothelial linings), urokinase-specific loosely packed macrophages within stromal septa. Both prominently expressed interstitial macrophages. A weaker was demonstrated. Inflammatory T lymphocytes located aggregates diffusely spread The reaction intense border