ERG/TFF3/HMWCK triple immunostain for detection of prostate cancer

作者: Mark A. Rubin , Kyung Park , Juan Miguel Mosquera , Francesca Demichelis , Ya-Lin Chiu

DOI:

关键词:

摘要: This invention relates to a triple immunostaining assay (ERG/TFF3/HMWCK) for sensitive and specific detection of prostate cancer. Positive staining at least one ERG or TFF3 combined with negative HMWCK in sample such as tissue is indicative

参考文章(19)
Allan D. Pronovost, Jan Pawlak, Gerald L. Rowley, Immunoassay using dye complexed enzyme conjugates. ,(1993)
Lisa M. Sapinoso, Jessica Wang-Rodriguez, John B. Welsh, Christopher A. Moskaluk, Suzanne G. Kern, Andrew I. Su, Henry F. Frierson, Garret M. Hampton, Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Research. ,vol. 61, pp. 5974- 5978 ,(2001)
William J. Catalona, Torsten Ehrig, Jeffrey Milbrandt, Peter A. Humphrey, Jeffrey A. Magee, Lawrence True, Sushama Patil, Mark A. Watson, Toshiyuki Araki, Expression Profiling Reveals Hepsin Overexpression in Prostate Cancer Cancer Research. ,vol. 61, pp. 5692- 5696 ,(2001)
David S. Rickman, Ying-bei Chen, Samprit Banerjee, Yihang Pan, Jindan Yu, Terry Vuong, Sven Perner, Christopher J. Lafargue, Kirsten D. Mertz, Sunita R. Setlur, Kanishka Sircar, Arul M. Chinnaiyan, Tarek A. Bismar, Mark A. Rubin, Francesca Demichelis, ERG Cooperates with Androgen Receptor in Regulating Trefoil Factor 3 in Prostate Cancer Disease Progression Neoplasia. ,vol. 12, pp. 1031- 1040 ,(2010) , 10.1593/NEO.10866
Wolfgang Jagla, Antje Wiede, Knut Dietzmann, Karen Rutkowski, Werner Hoffmann, Co-localization of TFF3 peptide and oxytocin in the human hypothalamus The FASEB Journal. ,vol. 14, pp. 1126- 1131 ,(2000) , 10.1096/FASEBJ.14.9.1126
Scott A. Tomlins, Anders Bjartell, Arul M. Chinnaiyan, Guido Jenster, Robert K. Nam, Mark A. Rubin, Jack A. Schalken, ETS Gene Fusions in Prostate Cancer: From Discovery to Daily Clinical Practice European Urology. ,vol. 56, pp. 275- 286 ,(2009) , 10.1016/J.EURURO.2009.04.036
Jacques Lapointe, Chunde Li, Craig P. Giacomini, Keyan Salari, Stephanie Huang, Pei Wang, Michelle Ferrari, Tina Hernandez-Boussard, James D. Brooks, Jonathan R. Pollack, Genomic Profiling Reveals Alternative Genetic Pathways of Prostate Tumorigenesis Cancer Research. ,vol. 67, pp. 8504- 8510 ,(2007) , 10.1158/0008-5472.CAN-07-0673
Rohit Mehra, Meredith M. Regan, Sven Perner, Elizabeth M. Genega, Gerri Bueti, Rajal B. Shah, Sandra Gaston, Scott A. Tomlins, John T. Wei, Michael C. Kearney, Laura A. Johnson, Jeffrey M. Tang, Arul M. Chinnaiyan, Mark A. Rubin, Martin G. Sanda, Juan-Miguel Mosquera, Prevalence of TMPRSS2-ERG Fusion Prostate Cancer among Men Undergoing Prostate Biopsy in the United States Clinical Cancer Research. ,vol. 15, pp. 4706- 4711 ,(2009) , 10.1158/1078-0432.CCR-08-2927
Scott A. Tomlins, Daniel R. Rhodes, Jianjun Yu, Sooryanarayana Varambally, Rohit Mehra, Sven Perner, Francesca Demichelis, Beth E. Helgeson, Bharathi Laxman, David S. Morris, Qi Cao, Xuhong Cao, Ove Andrén, Katja Fall, Laura Johnson, John T. Wei, Rajal B. Shah, Hikmat Al-Ahmadie, James A. Eastham, Scott E. Eggener, Samson W. Fine, Kristina Hotakainen, Ulf-Håkan Stenman, Alex Tsodikov, William L. Gerald, Hans Lilja, Victor E. Reuter, Phillip W. Kantoff, Peter T. Scardino, Mark A. Rubin, Anders S. Bjartell, Arul M. Chinnaiyan, The role of SPINK1 in ETS rearrangement-negative prostate cancers. Cancer Cell. ,vol. 13, pp. 519- 528 ,(2008) , 10.1016/J.CCR.2008.04.016