IFN-γ-release assays in the management of tuberculosis
作者： Graham H Bothamley
关键词:
摘要: New blood tests for TB are now available. One measures the release of IFN-γ and other estimates number cells secreting after stimulation with antigens from Mycobacterium tuberculosis. The choice (esat-6 cfp-10) is intended to distinguish infection Bacille Calmette–Guerin vaccination. Tests differ in lymphocyte numbers, use an additional antigen (TB7.7 – Rv2654) sensitivity concurrent HIV infection. Their role routine diagnosis limited. In latent infection, new correlate better exposure TB. However, time course immune response, significance negative tests, conversions positive vice versa their value predicting who will develop not yet known. Prospective studies these needed establish practical rather than theoretical Cohorts both immunocompetent immunosuppressed subjects may active disease...
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