The effect of corticosteroid or methotrexate therapy on lung lymphocytes and macrophages in sarcoidosis
作者： Robert P. Baughman , Elyse E. Lower
DOI: 10.1164/AJRCCM/142.6_PT_1.1268
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摘要: Methotrexate appears to be an effective alternative corticosteroid therapy for some patients with sarcoidosis. The mechanism of action methotrexate as immunosuppressive is unknown. Patients symptomatic pulmonary sarcoidosis underwent function tests and bronchoscopy bronchoalveolar lavage. were treated 10 mg or prednisone weekly at least 6 months repeat studies performed. A comparison was made between those receiving (12 patients) patients). For both groups, there a significant improvement in the vital capacity (Prednisone: Pre = 2.5 ± 0.14 L (Mean SEM); Post 3.1 0.18 L, p < 0.01; Methotrexate: 2.4 L; 2.8 0.01). In addition, percentage lymphocytes lavage fell significantly (Pre: 30 3.5%; Post: 16 2.7%, 0.001) 37 3.4%; 13 2.9%, groups. Alv...
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