Bifunctional boronic compound complexing reagents and complexes
作者： Clarence N. Ahlem , Mark L. Stolowitz , Robert J. Kaiser , Kevin P. Lund
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摘要: Embodiments include reagents to modify a bioactive species for incorporating bifunctional boronic compound complexing moiety subsequent conjugation different or same having pendant phenylboronic acid moieties of General Formula I, wherein group R is an electrophilic nucleophilic suitable reaction the putative reagent with species, 2 selected from one H and OH moieties, 3 alkyl methylene bearing electronegative substituent. Group Z spacer (CH ) n CH O(CH O) n2 , integer 1 5, 4. need not be same.
lens.org参考文章(44)
Kay Brune, Carboxylic acid amides, compositions and medical use thereof ,(1988)
Piggott Henry Alfred, Boric acid esters ,(1935)
Nonradioactive labeling and detection of biomolecules Springer-Verlag. ,(1992) , 10.1007/978-3-662-00144-8
Meir Wilchek, Edward A. Bayer, Introduction to avidin-biotin technology. Methods in Enzymology. ,vol. 184, pp. 5- 13 ,(1990) , 10.1016/0076-6879(90)84256-G
Peter D. G. Dean, Peter J. Brown, Vasilis Bouriotis, Method and kit for separation of glycoproteins ,(1979)
Kirsten J. Van der Merwe, Alfred Polson, Carrier-bound immunogenic determinants and carrier therefor ,(1986)
Thomas Horn, Michael S. Urdea, Method for making nucleic acid probes ,(1988)
Adrian D. Nunn, Kondareddiar Ramalingam, Karen E. Linder, Boronic acid adducts of metal dioxime complexes useful in labelling proteins and other amine-containing compounds ,(1991)
Ellen Myra Dobrusin, Howard Daniel Hollis Showalter, William Alexander Denny, Moana Tercel, Gordon William Rewcastle, Brian Desmond Palmer, Andrew Mark Thompson, 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and which have antitumor properties ,(1993)
Thomas Horn, Michael S. Urdea, Nucleic acid probes ,(1986)