Stereoselective Total Synthesis of Macrolide Sch-725674 and C-7-epi-Sch-725674
作者： Karunakar Baikadi , Anil Talakokkula , A Venkat Narsaiah , None
关键词:
摘要: The stereoselective total synthesis of Sch-725674 in 14 linear synthetic steps with 10.3% overall yield is described. started from commercially available starting materials, d -ribose and (R)-benzyl glycidol. key reactions involved CBS reduction, Julia–Kocienski olefination, Horner–Wadsworth–Emmons reaction, Shiina macrolactonization.
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