Metabolic side effects of antipsychotics: focus on hyperglycemia and diabetes.

摘要: Approximately 16 million people in the United States have diabetes, and World Health Organization has estimated that worldwide prevalence of diabetes will more than double from 1995 to 2025. Type 2 most common form may be 4 times prevalent patients with severe mental disorders. Within psychiatric community, there is a great deal concern about as potential side effect antipsychotic agents. An important population remember context treatment-emergent hyperglycemia 20 impaired glucose tolerance (IGT) (fasting plasma > 110 mg/dL 140 < 200 according American Diabetes Association). This prediabetic condition 5% 10% annual risk converting diabetes. One hypothesis for during double-blind, randomized, controlled trials who develop soon after initiation drug therapy schizophrenia had undiagnosed IGT or before they started treatment. The emergence clinical practice due an observation effect, but because incidence greater illnesses, it crucial psychiatrists aware national guidelines diagnosis treatment type