Anti-obesity effect of garlic oil on obese rats via Shenque point administration.

摘要: Abstract Ethnopharmacological relevance Shenque is an acupoint located in the umbilicus and connected with meridians. Thus, herbs applied at plays a pivotal role Chinese traditional medicine due to its sensitivity, permeability, absorption. Many studies reported use of point as successful therapeutic approach. However, effect garlic oil (GO) combat obesity unmet. Consequently, we investigated potential benefit GO against obesity. Aim study To investigate effects on obese rats orally administered, identify chemical constituents GO. Materials methods Rats were randomly divided into 2 groups: naive model group. The group fed high fat diet for 7 weeks induce obesity, then they 5 model, treated groups (25, 50 100 mg/kg/day) oral (50 mg/kg/day). Biochemical indexes serum, weight adipose tissue liver histopathology evaluated after 6 treatment using Hitachi 7080 analyzer (Hitachi, Japan). Moreover, components detected by gas chromatography-mass spectrometer (GC-MS). Results Compared rats, exhibited higher body weight, increased deposition, triglyceride concentration alveolar development. In contrast, showed substantial decrease (P = 0.358, 0.028, 0.031, respectively), mass, cholesterol (P = 0.004, 0.041, 0.001, (P = 0.001, low density lipoprotein concentrations 0.000, respectively). was more remarkable than administered. addition, twelve organosulfur compounds identified GC-MS diallyl trisulfide (DATS) main compound, 32.08% concentration. Conclusions These findings demonstrated that had significant anti-obesity reducing protecting from damage, better administration, suggesting effective weight-loss drug administration might be considered new