Roles of c-Met and RON kinases in tumor progression and their potential as therapeutic targets.

摘要: c-Met and receptor originated from nantes (RON) are structurally related transmembrane phosphotyrosine kinase receptors. RON show increased expression or activity in a variety of tumors leading to tumor progression may play role acquired resistance therapy. Although often co-expressed, the distinct functional roles not fully understood. form both activated homodimers heterodimers with themselves other families Inhibitors for including small molecular weigh inhibitors neutralizing antibodies pre-clinical investigation clinical trials. Several tyrosine have against kinases whereas generally target specific. As many targeted agents used treat solid tumors, it is likely that c-Met/RON will greater benefit when combination chemotherapy agents. A careful analysis better elucidation how they influence cell signaling be useful predicting which respond best these as well determining can combined