Hormone receptor and c-ERBB2 status in distant metastatic and locally recurrent breast cancer. Pathologic correlations and clinical significance.

摘要: Estrogen receptor (ER), progesterone (PR), and c-ERBB2 (HER2/neu) are therapeutically prognostically important markers in the management of breast carcinoma. They not always analyzed distant metastatic locally recurrent cancers. We compared immunohistochemical expression a series primary carcinomas with their metastases (n = 72) local recurrences 45) impact any changes on survival. Discordance rates between lesions, respectively, were 18% (13/72) 13% (6/45) for ER, 42% (30/72) 33% (15/45) PR, 7% (5/72) 2% (1/45) c-ERBB2. There was statistically significant discordance PR status (P .017; κ 0.201). Among tumors, 15 (33%) 45 revealed .006; 0.366). observed trend shorter survival among women ER– tumors regardless tumor ER status. Our findings suggest benefit routine evaluation cancer therapeutic prognostic purposes. About 60% to 70% express protein, these associated better prognosis. 1 Detecting depends physiologic technical factors, including menopausal status, endocrine therapy, sampling intratumoral heterogeneity, tissue fixation, method examination (biochemical, immunohistochemical), type antibody used. 2-4