Translocation of indigenous bacteria from the gastrointestinal tract of mice after oral ricinoleic acid treatment.

摘要: A single dose of ricinoleic acid, the active component castor oil, administered intragastrically to specific pathogen-free mice produced significant alterations in proximal small intestinal mucosa. Two hours after drug administration, duodenal villi were markedly shortened with massive exfoliation columnar and goblet cells. This disruption mucosal barrier resulted continuity between lumen lamina propria villi. Because loss barrier, bacteria indigenous gastrointestinal flora translocated from mesenteric lymph nodes, spleen, liver. The peak incidence bacterial translocation occurred 4 days acid treatment. Strictly anaerobic bacteria, which normally colonize tract at greater levels than aerobic or facultatively a nodes other bacteria. mucosa began regenerating within h treatment viable no longer cultured by 7