Current status and future directions of high-throughput ADME screening in drug discovery
作者： Wilson Z. Shou
DOI: 10.1016/J.JPHA.2020.05.004
关键词:
摘要: … part of any drug discovery effort of synthetic molecules. The conduct of HT-ADME screening has been “industrialized” due to the extensive development of software and automation tools …
sci-hub.st 参考文章(123)
Jan Wenzel, Hans Matter, Friedemann Schmidt, Predictive Multitask Deep Neural Network Models for ADME-Tox Properties: Learning from Large Data Sets Journal of Chemical Information and Modeling. ,vol. 59, pp. 1253- 1268 ,(2019) , 10.1021/ACS.JCIM.8B00785
Ian Sinclair, Martin Bachman, Daniel Addison, Mattias Rohman, David C. Murray, Gareth Davies, Elizabeth Mouchet, Michael E. Tonge, Richard G. Stearns, Lucien Ghislain, Sammy S. Datwani, Lars Majlof, Eric Hall, Gareth R. Jones, Emmy Hoyes, Joe Olechno, Richard N. Ellson, Perdita E. Barran, Steven D. Pringle, Michael R. Morris, Jonathan Wingfield, Acoustic Mist Ionization Platform for Direct and Contactless Ultrahigh-Throughput Mass Spectrometry Analysis of Liquid Samples Analytical Chemistry. ,vol. 91, pp. 3790- 3794 ,(2019) , 10.1021/ACS.ANALCHEM.9B00142
Luca Docci, Neil Parrott, Stephan Krähenbühl, Stephen Fowler, Application of New Cellular and Microphysiological Systems to Drug Metabolism Optimization and Their Positioning Respective to In Silico Tools SLAS DISCOVERY: Advancing the Science of Drug Discovery. ,vol. 24, pp. 523- 536 ,(2019) , 10.1177/2472555219831407
Leonardo L.G. Ferreira, Adriano D. Andricopulo, ADMET modeling approaches in drug discovery. Drug Discovery Today. ,vol. 24, pp. 1157- 1165 ,(2019) , 10.1016/J.DRUDIS.2019.03.015
Scott D. Edmondson, Bin Yang, Charlene Fallan, Proteolysis targeting chimeras (PROTACs) in 'beyond rule-of-five' chemical space: Recent progress and future challenges. Bioorganic & Medicinal Chemistry Letters. ,vol. 29, pp. 1555- 1564 ,(2019) , 10.1016/J.BMCL.2019.04.030
Elias C Padilha, Jianyao Wang, Ed Kerns, Arthur Lee, Wenwei Huang, Jian-kang Jiang, John McKew, Abdul Mutlib, Rosangela G Peccinini, Paul B Yu, Philip Sanderson, Xin Xu, None, Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). Frontiers in Pharmacology. ,vol. 10, pp. 234- ,(2019) , 10.3389/FPHAR.2019.00234
Amita Datta-Mannan, Mechanisms Influencing the Pharmacokinetics and Disposition of Monoclonal Antibodies and Peptides Drug Metabolism and Disposition. ,vol. 47, pp. 1100- 1110 ,(2019) , 10.1124/DMD.119.086488
Xianmei Cai, Shilpa Madari, Aaron Walker, Anthony Paiva, Ying Li, John Herbst, Wilson Shou, Harold Weller, Addition of Optimized Bovine Serum Albumin Level in a High-Throughput Caco-2 Assay Enabled Accurate Permeability Assessment for Lipophilic Compounds. SLAS DISCOVERY: Advancing the Science of Drug Discovery. ,vol. 24, pp. 738- 744 ,(2019) , 10.1177/2472555219848483
Diane Ramsden, Jing-Tao Wu, Brad Zerler, Sajida Iqbal, Jim Jiang, Valerie Clausen, Krishna Aluri, Yongli Gu, Sean Dennin, Joohwan Kim, Saeho Chong, In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters. Drug Metabolism and Disposition. ,vol. 47, pp. 1183- 1194 ,(2019) , 10.1124/DMD.119.087098
Alexander Kasperkiewicz, Germán Augusto Gómez-Ríos, Dietmar Hein, Janusz Pawliszyn, Breaching the 10 Second Barrier of Total Analysis Time for Complex Matrices via Automated Coated Blade Spray. Analytical Chemistry. ,vol. 91, pp. 13039- 13046 ,(2019) , 10.1021/ACS.ANALCHEM.9B03225