Nitric Oxide Deficiency and Endothelial Dysfunction in Pulmonary Arterial Hypertension

摘要: Nitric oxide (NO) signaling plays a major role in modulating vascular tone and remodeling the pulmonary circulation, but its pathogenesis of diseases is still not completely understood. Numerous abnormalities NO synthesis have been identified animal models disease humans with hypertension. Many these become targets new therapies for treatment However, it unclear to what extent alterations contribute hypertensive responses or merely reflect induced by underlying disease. This perspective examines current understanding altered discusses how may The efficacy limitations presently available hypertension that target are reviewed along an update on investigational use this pathway reverse changes.