Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use
作者： Kota V. Ramana , Satish K. Srivastava
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摘要: Provided herein is a crystallized ternary structure of aldose reductase (AR) bound to NADPH and γ-glutamyl-S-(1,2-dicarboxyethyl)cysteinylglycine (DCEG). Also provided are specific inhibitors glutathione-aldehyde binding which designed via at least computer modeling the AR:NADPH:DCEG methods designing screening for inhibition reductase. In addition treating pathophysiological state or symptoms thereof resulting from reductase-mediated signaling in cytotoxic pathway using small interfering RNA (siRNA) inhibitors.
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