Pseudogene-Expressed RNAs: Emerging Roles in Gene Regulation and Disease

摘要: Pseudogenes have for long been considered as non-functional relics littering the human genome. Only now, it is becoming apparent that many pseudogenes are transcribed into noncoding RNAs, some with proven biological functions. Here, we review current knowledge of and their widespread functional properties an emphasis on functionally investigated in greater detail. emerging a novel class RNAs functioning, example, through microRNA sponging chromatin remodeling. The examples discussed herein underline pseudogene-encoded important regulatory molecules involved diseases such cancer.