Human lung adenocarcinoma cells with an EGFR mutation are sensitive to non-autophagic cell death induced by zinc oxide and aluminium-doped zinc oxide nanoparticles.

摘要: Lung cancer, mostly non-small cell lung cancer (NSCLC), is the leading cause of deaths; however, efficient treatments for NSCLC remain insufficient. The objective this study was to investigate effects an epidermal growth factor receptor (EGFR) mutation on autophagic death in human adenocarcinoma cells by 20-nm zinc oxide nanoparticles (ZnONP20) and aluminum-doped ZnONPs (Al-ZnONP20). Two types were used throughout study: wild-type EGFR A549 EGFR-mutated CL1-5 cells. We observed that a significant reduction viability resulting from ZnONP20 Al-ZnONP20 occurred after 18 24 hr exposure. A colony formation analysis showed re-grew exposure 20 μg/mL Al-ZnONP20. Levels light chain 3 (LC3) II conversion activated cells, whereas LC3 inhibited In conclusion, we have shown with are sensitive Al-ZnONP20, which may resulted non-autophagic death. potential personalized therapeutics mutation.