Durable complete response of hepatocellular carcinoma after metronomic capecitabine.

摘要: Background. Hepatocellular carcinoma (HCC) is a highly vascular tumor which poorly responsive to standard systemic chemotherapy. Recently, various antiangiogenic targeted agents have shown promising activity at different levels of evidence in patients with advanced HCC, suggesting that such treatments might be effective. Case report. Since chemotherapy administered metronomic schedules inhibits angiogenesis, we treated 64-year-old man HCC capecitabine. After only two months treatment the nodules disappeared on ultrasonography. This finding was confirmed by computed tomography scan. more than three years patient still minimal toxicity and maintains complete remission. Conclusions. Our case report suggests capecitabine may effective while being also well tolerated. important, given frequent comorbidities patients. Free full text available