Phosphodiesterase-4 inhibitor in the treatment of psoriasis and psoriatic arthritis

摘要: Treatment of psoriasis and psoriatic arthritis, especially moderate severe, represents difficulties. Recently, various methods molecular medicine have been actively developed, however, targeted therapy deserves special attention, which consists chemical agents that specific target as a protein or enzyme. Targeted is promising direction in many branches medicine, dermatology. Despite the wide range biological products, their use may be accompanied by an increased risk infectious processes malignant neoplasms, makes search for new pharmacological solution even more relevant. This review presents possibilities prospects therapeutic phosphodiesterase-4 inhibitor from group small molecules — apremilast, primarily treatment arthritis.