Possible Involvement of IL-21 and IL-10 on Salivary IgA Levels in Chronic Periodontitis Subjects
作者： M. H. Napimoga , L. H. A. C. Nunes , A. A. B. Maciel , A. P. D. Demasi , B. B. Benatti
DOI: 10.1111/J.1365-3083.2011.02605.X
关键词:
摘要: Specific cytokines and the costimulatory protein CD40 play role in inducing immunoglobulin (Ig)A production by B cells humoral immune response. However, to date, of these mediators was not investigated chronic periodontitis. Therefore, aim this study assess local levels interleukin (IL)-21, IL-21 receptor (IL-21R), IL-4, IL-10 ligand (CD40L) on periodontitis subjects their relationship with salivary IgA. Gingival biopsies un-stimulated saliva were collected from (n = 15) periodontally healthy subjects. The mRNA IL-10, IL-21, IL-21R, CD40L gingival evaluated quantitative real-time polymerase chain reaction. IgA IL-4 analyzed ELISA. mean significantly higher compared group (P < 0.05). for 0.05) when group. expression IL-21R did differ between groups. elevated at Conversely, as well amount lower than ones. In conclusion, upregulation downregulation tissues may be collectively involved increased
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