Non-canonical role of the SNARE protein Ykt6 in autophagosome-lysosome fusion

作者: Szabolcs Takáts , Gábor Glatz , Győző Szenci , Attila Boda , Gábor V. Horváth

DOI: 10.1371/JOURNAL.PGEN.1007359

关键词:

摘要: … , Ykt6 can be outcompeted from this SNARE complex by Vamp7, and we demonstrate that overexpression of Vamp7 rescues the fusion defect of ykt6 … We find that Ykt6 can form a less …

参考文章(68)
Ryouichi Fukuda, James A. McNew, Thomas Weber, Francesco Parlati, Thomas Engel, Walter Nickel, James E. Rothman, Thomas H. Söllner, Functional architecture of an intracellular membrane t-SNARE Nature. ,vol. 407, pp. 198- 202 ,(2000) , 10.1038/35025084
James A. McNew, Francesco Parlati, Ryouichi Fukuda, Robert J. Johnston, Keren Paz, Fabienne Paumet, Thomas H. Söllner, James E. Rothman, Compartmental specificity of cellular membrane fusion encoded in SNARE proteins Nature. ,vol. 407, pp. 153- 159 ,(2000) , 10.1038/35025000
Hao Xu, Julie A. Brill, John Hsien, Rachel McBride, Gabrielle L. Boulianne, William S. Trimble, Syntaxin 5 Is Required for Cytokinesis and Spermatid Differentiation in Drosophila Developmental Biology. ,vol. 251, pp. 294- 306 ,(2002) , 10.1006/DBIO.2002.0830
Meik Dilcher, Beate Köhler, Gabriele Fischer von Mollard, Genetic Interactions with the Yeast Q-SNARE VTI1Reveal Novel Functions for the R-SNARE YKT6 Journal of Biological Chemistry. ,vol. 276, pp. 34537- 34544 ,(2001) , 10.1074/JBC.M101551200
Claudio Marcelo Fader, Diego Germán Sánchez, María Belén Mestre, María Isabel Colombo, TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochimica et Biophysica Acta. ,vol. 1793, pp. 1901- 1916 ,(2009) , 10.1016/J.BBAMCR.2009.09.011
M. Renna, C. Schaffner, A. R. Winslow, F. M. Menzies, A. A. Peden, R. A. Floto, D. C. Rubinsztein, Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex. Journal of Cell Science. ,vol. 124, pp. 469- 482 ,(2011) , 10.1242/JCS.076489
Wenyu Wen, Jiang Yu, Lifeng Pan, Zhiyi Wei, Jingwei Weng, Wenning Wang, Yan Shan Ong, Ton Hoai Thi Tran, Wanjin Hong, Mingjie Zhang, Lipid-Induced Conformational Switch Controls Fusion Activity of Longin Domain SNARE Ykt6 Molecular Cell. ,vol. 37, pp. 383- 395 ,(2010) , 10.1016/J.MOLCEL.2010.01.024
Wanjin Hong, SNAREs and traffic. Biochimica et Biophysica Acta. ,vol. 1744, pp. 120- 144 ,(2005) , 10.1016/J.BBAMCR.2005.03.014
Christoph T. A. Meiringer, Kathrin Auffarth, Haitong Hou, Christian Ungermann, Depalmitoylation of Ykt6 Prevents its Entry into the Multivesicular Body Pathway Traffic. ,vol. 9, pp. 1510- 1521 ,(2008) , 10.1111/J.1600-0854.2008.00778.X
James A. McNew, Morten Søgaard, Nina M. Lampen, Sachiko Machida, R. Ruby Ye, Lynne Lacomis, Paul Tempst, James E. Rothman, Thomas H. Söllner, Ykt6p, a Prenylated SNARE Essential for Endoplasmic Reticulum-Golgi Transport Journal of Biological Chemistry. ,vol. 272, pp. 17776- 17783 ,(1997) , 10.1074/JBC.272.28.17776