A Pilot Study Measuring the Distribution and Permeability of a Vaginal HIV Microbicide Gel Vehicle Using Magnetic Resonance Imaging, Single Photon Emission Computed Tomography/Computed Tomography, and a Radiolabeled Small Molecule
作者： Edward J. Fuchs , Jill L. Schwartz , David R. Friend , Jenell S. Coleman , Craig W. Hendrix
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摘要: Abstract Vaginal microbicide gels containing tenofovir have proven effective in HIV prevention, offering the advantage of reduced systemic toxicity. We studied vaginal distribution and effect on mucosal permeability a gel vehicle. Six premenopausal women were enrolled. In Phase 1, spreading 99mtechnetium-DTPA (99mTc) radiolabel gadolinium contrast for magnetic resonance imaging (MRI) was dosed intravaginally. MRI obtained at 0.5, 4, 24 h, single photon emission computed tomography with conventional (SPECT/CT) 1.5, 5, 25 h postdosing. Pads tissues measured activity to determine loss. 2, nonoxynol-9 (N-9), 99mTc-DTPA, as control; blood urine both phases. SPECT/CT showed throughout vagina highest concentration radiosignal fornices ectocervix; signal intensity diminished over 25 h. ...
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Lut Van Damme, Gita Ramjee, Michel Alary, Bea Vuylsteke, Verapol Chandeying, Helen Rees, Pachara Sirivongrangson, Léonard Mukenge Tshibaka, Virginie Ettiègne-Traoré, Charn Uaheowitchai, Salim S Abdool Karim, Benoît Mâsse, Jos Perriëns, Marie Laga, Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial The Lancet. ,vol. 360, pp. 971- 977 ,(2002) , 10.1016/S0140-6736(02)11079-8
Deborah Tien, Roger L. Schnaare, Feirong Kang, Gina Cohl, Timothy J. McCormick, Thomas R. Moench, Gustavo Doncel, Karen Watson, Robert W. Buckheit, Mark G. Lewis, Jill Schwartz, Karen Douville, Joseph W. Romano, In Vitro and in Vivo Characterization of a Potential Universal Placebo Designed for Use in Vaginal Microbicide Clinical Trials AIDS Research and Human Retroviruses. ,vol. 21, pp. 845- 853 ,(2005) , 10.1089/AID.2005.21.845
Kurt T. Barnhart, E. Scott Pretorius, Alka Shaunik, Kelly Timbers, Marlina Nasution, Christine Mauck, Vaginal distribution of two volumes of the novel microbicide gel cellulose sulfate (2.5 and 3.5 mL) Contraception. ,vol. 72, pp. 65- 70 ,(2005) , 10.1016/J.CONTRACEPTION.2005.02.006
Nicolette A. Louissaint, Edward J. Fuchs, Rahul P. Bakshi, Sridhar Nimmagadda, Yong Du, Katarzyna J. Macura, Karen E. King, Richard Wahl, Arthur J. Goldsmith, Brian Caffo, Ying Jun Cao, Jean Anderson, Craig W. Hendrix, Distribution of Cell-Free and Cell-Associated HIV Surrogates in the Female Genital Tract After Simulated Vaginal Intercourse The Journal of Infectious Diseases. ,vol. 205, pp. 725- 732 ,(2012) , 10.1093/INFDIS/JIR841
Kurt Thomas Barnhart, E. Scott Pretorius, Kelly Timbers, David Shera, Mayadah Shabbout, Daniel Malamud, In vivo distribution of a vaginal gel: MRI evaluation of the effects of gel volume, time and simulated intercourse Contraception. ,vol. 70, pp. 498- 505 ,(2004) , 10.1016/J.CONTRACEPTION.2004.06.013
Kurt T. Barnhart, E. Scott Pretorius, David M. Shera, Mayadah Shabbout, Alka Shaunik, The optimal analysis of MRI data to quantify the distribution of a microbicide. Contraception. ,vol. 73, pp. 82- 87 ,(2006) , 10.1016/J.CONTRACEPTION.2005.07.005
E.Scott Pretorius, Kelly Timbers, Dan Malamud, Kurt Barnhart, Magnetic resonance imaging to determine the distribution of a vaginal gel: before, during, and after both simulated and real intercourse. Contraception. ,vol. 66, pp. 443- 451 ,(2002) , 10.1016/S0010-7824(02)00412-2
Christine K. Mauck, David Katz, Erik P. Sandefer, Marlina D. Nasution, Marcus Henderson, George A. Digenis, Irene Su, Richard Page, Kurt Barnhart, Vaginal distribution of Replens and K-Y Jelly using three imaging techniques. Contraception. ,vol. 77, pp. 195- 204 ,(2008) , 10.1016/J.CONTRACEPTION.2007.11.016
Kurt Barnhart, E.Scott Pretorius, Alan Stolpen, Daniel Malamud, Distribution of topical medication in the human vagina as imaged by magnetic resonance imaging Fertility and Sterility. ,vol. 76, pp. 189- 195 ,(2001) , 10.1016/S0015-0282(01)01822-2
E.Scott Pretorius, Kurt Barnhart, Kelly Timbers, Christine Mauck, Use of MRI to determine the in vivo position of a silicone vaginal barrier contraceptive device. Contraception. ,vol. 65, pp. 343- 346 ,(2002) , 10.1016/S0010-7824(02)00278-0